About the Journal

The American Journal of Toxicology and Pharmacological Research (AJTPR) is a peer-reviewed, open-access journal publishing advances across experimental and clinical toxicology, pharmacology, and safety sciences—from molecular mechanisms to population-level risk assessment.

AJTPR welcomes original research, reviews, short communications, methods/validation studies, case reports with mechanistic depth, regulatory science perspectives, and data/resource notes. Interdisciplinary work that integrates in vitro, in vivo, in silico, and clinical evidence is encouraged. Core areas include:

ADME/DMPK, transporters, drug–drug interactions
PBPK/QSP modeling, systems pharmacology
Immuno-, neuro-, hepato-, nephro-, and cardiotoxicity
Reproductive & developmental toxicology; teratology
Biomarkers, toxicogenomics/proteomics/metabolomics
Alternatives to animal testing: organ-on-chip, 3D models, AI
Occupational & environmental exposure; mixture toxicity
Pharmacovigilance, real-world evidence, benefit–risk
Regulatory science, risk assessment, and decision frameworks

Reporting & Ethics

Animal studies should follow ARRIVE guidelines; clinical/observational work should follow STROBE and trials CONSORT where applicable.
Systematic reviews should follow PRISMA; include search strategy and bias assessment.
Human research must include ethics approval and consent; ensure de-identification of all data/images.
Regulatory submissions should align with ICH M4 and relevant safety guidances.
Data and code availability statements are strongly encouraged.

Article Types

Original Research (~4,000–7,000 words)
Reviews / Mini-Reviews
Short Communications
Methods & Validation
Case Reports / Pharmacovigilance Notes
Regulatory & Policy Perspectives
Data/Resource Papers

Peer Review & Access

All manuscripts undergo rigorous double-blind peer review by subject-matter experts. As an open-access journal, AJTPR provides immediate, free access to its content to support global knowledge sharing and safer therapeutics.